Endocrine Abstracts

Introduction: Hepcidin is a reactive inflammatory protein, responsible for ferrum homeostasis. Its concentration was already measured in hyperthyroiditis in the course of Graves disease and after restoration of euthyroidism, but also in growth hormone deficiency, hyperprolactinemia, however no significant changes were noted. De Quervain thyroiditis is a rare type of subacute thyroid inflammation, caused by interplay of unknown infectious, genetic and autoimmune factors and res...

Introduction: Hepcidin is an acute-phase protein and a key regulator of iron homeostasis. Anemia frequently occurs in patients with hyperthyroidism, while hepcidin may be a potential link.Objectives: Prospective evaluation of hepcidin serum concentration and other parameters related to Fe homeostasis in group of hyperthyroid patients in the course of Graves’ disease (GD) at diagnosis and after restoration of euthyroidism.Pati...

Background: Immuglobulin 4 (IgG4) is the least common subtype of Immoglobulin G. However due to its unique characteristic it has been the focal point of many research projects, which eventualy led to the discovery of the sytemic fibro-inflammatory disorder called IgG4-Related Disease. The potential role of IgG4 in the pathogenesis of autoimmune thyroid diseases has been also suggested. However, the amount of evidence is still limited, especially in Graves Disease (GD).<p c...

Incidence of acute thyroiditis is about 0.1% of thyroid gland conditions requiring surgical treatment. Main pathogen causing acute thyroiditis is Staphylococcus aureus while Salmonella enterica is extremely rare.Herewith we report a 61-year-old obese woman with sore throat and fever. She had chronic atrial fibrillation, hypertension, and well-controlled type 2 diabetes mellitus (HbA1C 5.5%) for 3 years (on metformin and gliclazide). Her...

Introduction: Obstructive sleep apnea syndrome (OSAS) is characterized by chronic inflammation. Hepcidin is an acute-phase protein involved in iron metabolism. Increase in hepcidin has been shown in OSAS. Testosterone probably exerts inhibitory effect on hepcidin levels and even trump iron and inflammation-mediated mechanism in chronic inflammatory state. On the other hand iron balance may influence gonadal axis. The aim of this study was to assess whether hypogonadism in OSAS...

Background: ACTH-Independent Macronodular Adrenal Hyperplasia (AIMAH) is usually manifested as both-sided adrenal incidentalomas with subclinical overproduction of cortisol (<2% of Cushing’s syndrome). The pathogenesis involves genetic factors, expression of adrenal aberrant hormone receptors and paracrine adrenal corticotropin (ACTH) secretion. Treatment is usually bilateral adrenalectomy, but in some cases also unilateral adrenalectomy or pharmacologic therapy can b...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant condition characterized by varying combinations of endocrine tumors and commonly accompanying hyperplasia within the parathyroid gland, anterior pituitary and gastrointestinal tract. Heterozygous germline mutation of the tumor suppressor gene MEN1 is the most common cause of the disease. Molecular genetic testing of menin gene, in which mutation is known to cause MEN1 syndrome, detects pathogenic...

Purpose: Adrenal cancers are relatively rare, but they have poor prognosis. IGF2 has been confirmed as a factor of adrenal tumors development. Recent data indicate that ghrelin may be an essential factor in cancerogenesis. The aim of our study was to assess ghrelin expression in adrenal tumors, and to investigate the relationship between ghrelin, IGF2 and the clinicopathological characteristics. We also investigated the influence of ghrelin on adenocarcinoma cell line prolifer...